IndraLab
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reach
"While DOX treatment alone did not significantly alter expression of these genes in HeLa parental cells (XREF_FIG), expression of YOD1 WT or C160S caused a significant decline in NF-kappaB target gene induction after IL-1beta stimulation, indicating that YOD1 can antagonize IL-1R triggered NF-kappaB signaling independent of its catalytic activity."