IndraLab

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SIRT1 activates ATXN3. 3 / 3

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"Altogether, these results demonstrate that SIRT1 mediates the robust neuroprotective effects of CR in MJD."

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"We then investigated whether lentiviral overexpression of SIRT1 would be sufficient to mimic the effects of CR and mediate similar alleviation of MJD pathology."

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"These results suggest that in fact SIRT1 activates autophagy in MJD mice (XREF_FIG)."

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IndraLab

Statements

SIRT1 activates ATXN3. 3 / 3

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