IndraLab

Statements

Modified CCND1 leads to the phosphorylation of RB1. 2 / 2
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"DDT has also been shown to enhance proliferation by increasing the expression of Ccnd1 (cyclin D1)/E2f, inducing phosphorylation of pRb, increasing the expression of p53 degrading protein Mdm2 (a negative regulator of p53) and disrupting gap-junctional intercellular communication."
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"These findings indicated that Cdk6 and Ccnd1 overexpression inhibited chondrocyte maturation and enhanced G1/S cell-cycle transition by phosphorylating pRb, but the chondrocytes failed to accomplish the cell cycle, and underwent p53 dependent apoptosis probably due to the dysregulation of E2f target genes."
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