IndraLab

Statements

KCNH2 inhibits ion channel. 4 / 4
| 2 2
sparser
"TBAJ-876 ( xref ) was selected from this series to progress to pre-clinical development due to its lower lipophilicity, lower hERG ion channel inhibition, higher clearance and retention of BDQ’s potent activity against Mtb [ xref ]."
31835707
sparser
"Several heterocycles as well as different amido substituents were screened for their antiviral activity, oral bioavailability, and low propensity towards hERG ion channel inhibition and interaction with a range of CYP enzymes."
| PMC
reach
"To date, these formats have largely been used by pharmaceutical companies to screen for human ether-a-gogo-related gene (hERG) induced cardiac ion channel blockade (Möller and Witchel, 2011)."
30544081
reach
"These include off-target pharmacology, ion channel inhibition including hERG (human Ether-a-go-go-Related Gene), in vitro genotoxicity including Ames and micronucleus tests, and phototoxicity studies."
30526594