IndraLab

Statements

OTUD5 activates Cell Survival. 3 / 3
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"To discern whether OTUD5 could mitigate GPX4-mediated cell ferroptosis and enhance cell survival, we knocked down OTUD5 in HK2 cells using siRNA."
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"Specifically, the role of OTUD5 in stabilizing GPX4 suggests that therapeutic modulation of its activity might be a feasible strategy for controlling GPX4 levels, thus manipulating the course of ferroptosis and ultimately, the progression of AKI.Through a series of experiments, we demonstrate that OTUD5 plays a protective role against ferroptosis and contributes to cell survival."
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"To elaborate our understanding of OTUD5 functionality in NSCLC cells, we further overexpressed OTUD5 in A549 and HCI-H460 cells and learnt that OTUD5 overexpression led to a reduction in cell viability, migration, and invasion."
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