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USP1 inhibits enzalutamide. 2 / 2

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"Furthermore, we found that USP1 knockdown reduced tumorigenesis and promoted PC cell response to therapeutic agent enzalutamide in a KDM4A dependent manner."

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reach

"The supportive evidence is as follows : (i) USP1 knockdown decreased PC cell proliferation in vitro and tumorigenesis in vivo, and promoted the response to therapeutic agent enzalutamide; and (ii) inhibition of USP1 sensitized cancer cells to therapeutic agent enzalutamide, whereas this effect was blunted by overexpression of KDM4A."

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USP1 inhibits enzalutamide. 2 / 2

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