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USP13 increases the amount of TWIST1. 3 / 3
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"Moreover, we found that the level of Twist1 increased in a USP13 dose-dependent manner, but not that of USP13AE, when Twist1 was co-expressed with increasing amounts of USP13 or USP13AE in HEK293T cells (Fig. 1f)."
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"We found that USP13, when co-expressed with Twist1 in HEK293T cells, remarkably increased the protein, but not the mRNA level of Twist1, an effect comparable to that observed after treatment with 20 μM proteasome inhibitor MG132 (Fig. 1d and Fig. S2a)."
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"We found that in two cell lines, T47D and ZR-75–30, which represent typical luminal cells with undetected endogenous Twist1 expression, the expression of USP13 significantly increased the levels of Twist1 and its downstream proteins (Fig. 4f)."
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