
IndraLab
Statements
reach
"By constructing a network of protein-protein interactions (PPIs), we identified six key proteins (TNF, IL6, TLR4, IL1β, IL10, and IL8) that exhibited substantial interactions (more than 30 edges), suggesting their potential as significant targets for influencing malaria susceptibility."
reach
"The key and novel findings include : 1) Both hepatocyte and myeloid cell TLR4 is required for maximal I/R associated injury; 2) DC TLR4 -/- worsens injury after I/R and is associated with decreased IL-10 expression; 3) Hepatocytes are a major source of circulating HGMB1 after I/R; 4) Hepatocytes respond to hypoxia with increased phosphorylation of MAP kinases, JNK and p38, in a TLR4 dependent fashion; 5) Hypoxia induced HMGB1 release from hepatocytes is dependent on the function of JNK."