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USP22 decreases the amount of BAX. 2 / 2

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"We found that USP22 silencing in A549 and NCI-H460 cells increased the protein expression of p53, p21 and Bax, the key p53 signal molecules (XREF_FIG A), suggesting that p53 activation plays a role in USP22 silencing induced growth inhibition."

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"USP22 knockdown in anaplastic thyroid carcinoma cells induces mitochondria-dependent apoptotic pathway by upregulating levels of apoptotic protein, Bax and Bid, and activating caspase-3 [6]."

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USP22 decreases the amount of BAX. 2 / 2

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