IndraLab

Statements


E2F1 increases the amount of KCNH1. 3 / 5
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"The viral oncoprotein HPV E7 targets pRb, and the pRb/E2F-1 pathway directly regulates Kv10.1 transcription during G2/M (30–32)."

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"p53 activates miR-34 transcription; upregulation of miR-34 represses E2F1 and h-eag1; repression of E2F1 downregulates expression of h-eag1."

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"Because in the promotor region of the KCNH1 gene there exist E2F1-responsive elements, up-regulation of E2F1 increases the Kv10.1 levels and vice versa [40,68]."