IndraLab

Statements

CYLD activates CASP8. 4 / 5
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"Increased caspase-8 activation was also observed in selenite treated cells transfected with CYLD, indicating that CYLD promoted caspase-8 activation via RIP1 deubiquitination (XREF_FIG)."
24577083
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"An alternative explanation holds that CYLD is the target of caspase-8 during the decision point between apoptosis vs. necroptosis, although this model is not mutually exclusive from the aforementioned."
25364712
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"These changes in sensitivity to TNF-alpha cytoxicity, mediated by the treatment of siCLIPR-59 or siCYLD, correlated with differences in RIP1 ubiquitination (XREF_SUPPLEMENTARY) These findings thus suggest that both CLIPR-59 and CYLD are essential for activation of Caspase-8 by TNF-alpha in the presence of Compound-3."
22297296
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"CYLD was also found to promote the assembly of an alternative caspase-8 activating complex containing RIP1 and FADD [XREF_BIBR]."
20532807