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USP15 deubiquitinates IRS2. 4 / 4
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"Thus, IRS-2 deubiquitination by USP15 may also be induced/suppressed by some hormone(s), enabling the fine-tuning of IGF growth promoting action."
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"Co-expression of USP15 decreased Nedd4-induced IRS-2 ubiquitination, whereas co-expression of USP15 CS (inactive form of USP15 by substitution of the catalytic core cysteine residue at position 298 to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP15 knockdown increased Nedd4-induced IRS-2 ubiquitination ( Fig. 2 b)."
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"In this study, we found that USP15 antagonizes the effects of Nedd4; USP15 decreases Nedd4-dependent IRS-2 ubiquitination, and suppresses IRS-2 tyrosine phosphorylation and downstream IGF-I signaling.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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