IndraLab

Statements


Bisphenol A decreases the amount of CACNA1E. 2 / 4
2 | 2

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"Low-dose BPA represses Cav2.3 gene expression via ERβ, resulting in a decrease in Ca entry, while high-dose BPA activates ERα to enhance Ca current in a PI3K-dependen manner, thus reversing the downtrend at low doses."

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"The decrease in both the R-type Ca 2+ currents and Cacna1e gene expression by 1nM BPA implicated ERbeta."