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IGF2BP3 increases the amount of USP49. 5 / 5
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"Besides, Me‐RIP analysis demonstrated that IGF2BP3 overexpression significantly enhanced the m A methylation level of USP49, whereas IGF2BP3 knockdown reduced the m A methylation of USP49 (Figure 7K)."
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"In addition, we identified insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)-mediated N6-methyladenosine (m 6 A) modification of USP49 as a regulatory mechanism, wherein IGF2BP3 upregulated USP49 expression in an m 6 A-dependent manner."
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"Altogether, SIRT1 is required for USP49‐mediated malignant proliferation and CBP resistance in RB in vitro.3.7 IGF2BP3 upregulates USP49 expression in an m 6 A-dependent manner."
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"By using MeRIP‐qPCR and RIP‐qPCR assays, we demonstrated that IGF2BP3 upregulated USP49 expression by enhancing the m A level of USP49."
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"It was shown that IGF2BP3 overexpression significantly increased USP49 mRNA levels; conversely, IGF2BP3 deficiency exerted the opposite effects (Figure 7J)."
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