IndraLab

Statements

USP8 activates cell death. 3 / 3
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"Likewise, knockdown of Usp8 in Drosophila and human cells increased the lysosomal degradation of α-syn and reduced cell death (Alexopoulou et al., 2016)."
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"Although USP8 depletion suppresses cell proliferation in various cancer cells and induces cell death in some cell lines (Islam et al., 2021), whether a direct connection exists between USP8 and ferroptosis remains unknown."
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"To further investigate whether targeting USP8 induced cell death through ferroptosis, HCC cells treated with DUB‐IN‐3 or sg‐USP8 were incubated with ferrostatin (1 µm) for 24 h, then cell viability was determined using CCK8 assay."
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