IndraLab

Statements

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"USP15 knockdown significantly inhibited cell proliferation , invasion and epithelial-mesenchymal transition ( EMT ) of GC in vitro , while overexpression of USP15 promoted these processes ."
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"Rescue assays further suggested that USP15 promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"USP15 promotes cell proliferation, invasion and EMT progression of GC via regulating the Wnt and beta-catenin pathway, which suggests that USP15 is a novel potential therapeutic target for GC."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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"USP15 and USP4 induces cancer cell proliferation via regulating alternative splicing of SRSF1."
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"USP15 enhances the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TβRI in vitro."
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"Knockdown of USP15 without TGF-beta treatment promoted the cell proliferation."
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"USP15 overexpression promotes MM cell proliferation."
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"The authors hypothesized that USP15 was up-regulated and enhanced the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TGF-β receptor I (TβRI) in vitro."
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"Human pulmonary artery smooth muscle cells (hPASMCs) were exposed to hypoxia to mimic PH in vitro, and USP15 knockdown significantly inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxic hPASMCs."
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"XREF_FIG, PDTC treatment significantly inhibited the USP15 overexpression induced proliferation of RPMI 8226 and U266 cells by 24.9 and 29.2% at 48h after transfection, respectively."
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"USP15 promotes cell proliferation , invasion and EMT progression of GC via regulating the Wnt / beta-catenin pathway , which suggests that USP15 is a novel potential therapeutic target for GC ."
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"Overexpression of USP15 promoted proliferation and inhibited apoptosis, and these effects were inhibited by PDTC treatment."
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"Depletion of USP15 and USP4 decreased cell proliferation in both H157 (Fig. 1C and Supplementary Fig. 1C, D) and A549 (Supplementary Fig. 1E)."
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"38, 39, 40, 41 For example, USP15 upregulates the TGF-beta pathway to promote cell proliferation in glioblastoma pathogenesis."
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"PDTC treatment inhibits USP15 overexpression induced MM cell proliferation and apoptosis inhibition."
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition (EMT) of GC in vitro, while overexpression of USP15 promoted these processes."
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"As such, we hypothesized that USP15 may be able to promote HaCaT cell proliferation in part via altering the EIF4A1 expression."
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"Our data also revealed that USP15 mRNA and protein levels were upregulated in glioma tissues compared to those in adjacent normal brain tissues, that higher USP15 expression reflected a poor glioma prognosis and that USP15 overexpression promoted cell proliferation and migration."
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