IndraLab

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"As such, we hypothesized that USP15 may be able to promote HaCaT cell proliferation in part via altering the EIF4A1 expression."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition (EMT) of GC in vitro, while overexpression of USP15 promoted these processes."
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"In addition, the PRP-derived exosomes contain the key mediator USP15, which promotes the proliferation, migration, and tissue repair activity of immortalized keratinocytes by inducing the deubiquitination of EIF4A1 (Xu et al., 2021)."
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"USP15 overexpression promotes MM cell proliferation."
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"Human pulmonary artery smooth muscle cells (hPASMCs) were exposed to hypoxia to mimic PH in vitro, and USP15 knockdown significantly inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxic hPASMCs."
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"USP15 promotes cell proliferation, invasion and EMT progression of GC via regulating the Wnt/beta-catenin pathway, which suggests that USP15 is a novel potential therapeutic target for GC."
34326621
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition of GC cells in vitro and tumor growth in vivo."
34326621
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"Rescue assays further suggested that USP15 promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"The overexpression of USP15 promoted the capacity of proliferation, migration, and invasion in ccRCC CAKI1 and 769-P cells, and these malignant biological properties were diminished by USP15 deletion in 786-O cells."
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"Our data also revealed that USP15 mRNA and protein levels were upregulated in glioma tissues compared to those in adjacent normal brain tissues, that higher USP15 expression reflected a poor glioma prognosis and that USP15 overexpression promoted cell proliferation and migration."
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) of GC cells in vitro and tumor growth in vivo."
34326621
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"Knockdown of USP15 inhibits cell proliferation, invasion, and EMT progression of GC in vitro."
34326621
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"USP15 deficiency inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxia-induced hPASMCs."
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"Knockdown of USP15 without TGF-beta treatment promoted the cell proliferation."
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"Consistent with this notion, USP15 over-expression promoted proliferation of tumor cells (Supplementary Fig. 2a−c)."
38750011
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"USP15 overexpression promotes cell proliferation, invasion, and EMT progression in GC."
34326621
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"USP15 overexpression promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"To further explore whether USP15 mediated hPASMC proliferation and migration in a YAP1/TAZ-dependent manner, we achieved the depletion of YAP1 or TAZ in USP15-overexpressing hPASMCs by corresponding adenovirus infection."
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"USP15 depletion significantly decreased PTC cell proliferation, migration, and invasion."
38577597
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"PDTC treatment inhibits USP15 overexpression induced MM cell proliferation and apoptosis inhibition."
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"Thus, USP15 promotes tumor cell proliferation and tumor growth through maintaining TBX3 level and related downstream events.To understand how the proteostasis regulation fits in the in vivo highly spontaneous BRAF -induced tumorigenesis where Tbx3 is re-activated and critically required for tumor initiation and progression , we first collected tumor tissues from mPTC model generated by crossing thyroid peroxidase TPO-Cre with LSL-Braf (Supplementary Fig. 2h) ."
38750011
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"Collectively, these data demonstrated that USP15 overexpression promoted GC proliferation, invasion, and EMT progression."
34326621
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"Consequently, USP15 deficiency inhibits melanoma tumor cell proliferation and xenografted tumor growth in the TBX3-dependent manner, which is consistent with reported USP15 function in melanoma development (Fig. 5h, Supplementary Fig. 4d, e)."
38750011
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"Since MMP-mediated degradation of the basement membrane is a pivotal process for tumor metastasis [ 28 , 29 ], we determined whether MMPs can regulate USP15-mediated NSCLC cell proliferation and invas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"38, 39, 40, 41 For example, USP15 upregulates the TGF-beta pathway to promote cell proliferation in glioblastoma pathogenesis."
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"Furthermore, we found that USP15 promotes cell proliferation, migration, and invasion through HMGB1."
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"USP15 knockdown significantly inhibited cell proliferation , invasion and epithelial-mesenchymal transition ( EMT ) of GC in vitro , while overexpression of USP15 promoted these processes ."
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"In addition to promoting proliferation, migration, and invasion of ccRCC cells, USP15 accelerated tumor in situ growth and lung metastasis in experimental animals."
38847328
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"Strikingly, attenuation of USP15 expression greatly attenuated the proliferation, migration, and invasion of bladder cancer cells."
38656882
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"The above findings indicated that USP15 may promote cell proliferation, migration, invasion and EMT process to become an oncogene of GC."
34326621
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"USP15 depletion significantly decreased cell proliferation rate (Figure 5A) (PTC cell VS Ctrl and Vector, P<0.001)."
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"USP15 promotes cell proliferation , invasion and EMT progression of GC via regulating the Wnt / beta-catenin pathway , which suggests that USP15 is a novel potential therapeutic target for GC ."
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"XREF_FIG, PDTC treatment significantly inhibited the USP15 overexpression induced proliferation of RPMI 8226 and U266 cells by 24.9 and 29.2% at 48h after transfection, respectively."
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"Thus, we propose that USP15 might be a novel regulator of YAP1/TAZ signaling during PH progression.Our rescue assay determined that USP15 promoted the proliferation and migration of hypoxia-exposed PASMCs in a YAP1/TAZ-dependent manner."
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"In contrast, overexpression of USP15 promoted cell proliferation (Figure 5B) (PTC cell VS Ctrl and Vector, P<0.001)."
38577597
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"USP15 promotes bladder cancer proliferation in vivo."
38656882
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"Furthermore, USP15 promoted cell proliferation, invasion, and EMT progression via the Wnt/β-catenin signaling pathway in vitro and promoted the growth of GC cells in vivo."
34326621
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition of GC in vitro, while overexpression of USP15 promoted these processes."
34326621
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"Cell Counting Kit-8 assays demonstrated that USP15 knockdown significantly inhibited cell proliferation ( Figure 2 I)."
30980801
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"As shown by flow cytometry, the cell cycle was arrested at the G 0 /G 1 phase, with a decreased proportion of cells in the S phase, after inhibition of USP15 expression ( Figure 2 J), which further co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP15 can promote the proliferation and invasiveness of bladder cancer by mediating the NF-kappaB signaling pathway."
38656882
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"USP15 promotes cell proliferation, invasion, and EMT progression of GC via regulating the Wnt/β-catenin pathway."
34326621
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"Herein, we first revealed that USP15 could promote wound healing by enhancing the proliferation and migration of HDFs and activating the TGF-β signaling pathway, thereby providing a novel therapeutic [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, these results strongly suggest that USP15 promotes the proliferation, invasion, and migration of bladder cancer cells through the NF-κB pathway."
38656882
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"USP15 knockdown significantly impeded cell proliferation, invasion, epithelial-mesenchymal transition, and distal colonization in xenograft models, while enhancing oxaliplatin's antitumor effect."
39164728
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"Conclusion:. USP15 enhances the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TbetaRI in vitro."
34546211
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"Overexpression of USP15 promoted proliferation and inhibited apoptosis, and these effects were inhibited by PDTC treatment."
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"The results revealed that excessive expression of BRCC3 promoted the growth, invasion, and migration of bladder cancer cells and also counteracted the reduced proliferation and invasion caused by the inhibition of USP15 expression (Figure 7F)."
38656882
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"USP15 Promotes the Proliferation, Migration, and Invasion of Hypertrophic Scar-Derived Fibroblasts."
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"In summary, our study demonstrates that USP15 can activate the NF-κB signaling pathway through BRCC3, thus enhancing the proliferation, migration, and invasiveness of bladder cancer cells."
38656882
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"Cell Counting Kit-8 assays showed that USP15 knockdown significantly inhibited the proliferation of hypertrophic scar–derived fibroblasts (62.06 ± 10.46 percent; p < 0.05), whereas USP15 overexpression significantly promoted the proliferation of hypertrophic scar–derived fibroblasts (147.97 ± 10.49 percent; p < 0.05."
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"Here we described that USP15 promotes proliferation and inflammation in keratinocytes by stabilizing squamous cell carcinoma antigen 2 (SCCA2)."
37517516
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"(Right) The invasion of hypertrophic scar fibroblasts in blank, vector, and USP15 groups was detected by Matrigel invasion assays (*p < 0.05), http://links.lww.com/PRS/E646.] These results suggest that USP15 promotes the proliferation, migration, and invasion of hypertrophic scar–derived fibroblasts."
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"Depletion of USP15 and USP4 decreased cell proliferation in both H157 (Fig. 1C and Supplementary Fig. 1C, D) and A549 (Supplementary Fig. 1E)."
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"Deubiquitination enzyme USP15 and its similar parallel gene USP4 were overexpressed and promoted the proliferation of lung cancer cells by regulating SRSF1 alternative splicing (67)."
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"The Cell Counting Kit-8, scratch, and invasion assays showed that USP15 knockdown significantly inhibited the proliferation, migration, and invasion of the hypertrophic scar–derived fibroblasts, and USP15 overexpression showed the opposite trends."
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"USP15 and USP4 induces cancer cell proliferation via regulating alternative splicing of SRSF1."
35027535
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"In conclusion, USP15 enhances the proliferation, migration, and collagen deposition of hypertrophic scar–derived fibroblasts by deubiquitinating TβRI in vitro."
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"USP15 promotes tumor cell invasion and proliferation in GBM [40]."
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