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"Moreover, GSK3β knockdown in GSC11 cells attenuated the interaction between endogenous USP22 and KDM1A ( xref ), which was confirmed in 293T cells by transfection of GSK3β-KD as compared with GSK3β-CA ( xref )."

"At the same time, the loss of OTUD7B promotes the binding of LSD1 to P62, a polyubiquitin chain binding protein, leading to LSD1 proteasomal degradation. xref USP28 (ubiquitin-specific protease 28) catalyzes deubiquitination of LSD1 through the N-terminal region of USP28 and the AOL domain of LSD1 to stabilize LSD1 protein, which enables direct regulation of the expression of differentiation genes, indirectly regulating the expression of the pluripotency activators. xref In glioma, a lack of methionine inhibits the growth of cancer cells and enhances the binding of LSD1 to E3 ubiquitin ligase CBL (casitas B-lineage lymphoma), and increased ubiquitination of LSD1 enhances expression of CXCL8 (CXC motif chemokine ligand 8) and methylated histone H3, which in turn affects the metabolism of the glycerophospholipid. xref USP7 (ubiquitin-specific protease 7) is able to interact with LSD1, exercising deubiquitination functions and enhancing the inhibitory effect of LSD1 on p53 (tumor protein p53). xref , xref , xref Phosphorylation of LSD1 catalyzed by GSK3β promotes the binding of LSD1 to USP22 (ubiquitin specific protease 22), and deubiquitination of LSD1 promotes tumor formation. xref , xref USP38 (ubiquitin-specific protease 38) interacts with LSD1 at amino acid 454 to stabilize protein level."

"Using a series of KDM1A deletion mutants, we found that KDM1A 's AOL domain was required for KDM1A 's binding with USP22 (XREF_FIG)."

"Moreover, GSK3beta knockdown in GSC11 cells attenuated the interaction between endogenous USP22 and KDM1A (XREF_FIG), which was confirmed in 293T cells by transfection of GSK3beta-KD as compared with GSK3beta-CA (XREF_SUPPLEMENTARY)."

"Furthermore, KDM1A S683A significantly decreased the interaction between USP22 and KDM1A in the presence of GSK3beta-CA (XREF_FIG)."

"The target relationship of USP22 and miR-362-3p as well as the interaction of USP22 and LSD1 in RB was verified."

"The target relationship of USP22 and miR-362-3p as well as the interaction of USP22 and LSD1 in RB was verified."

"Likewise, glycogen synthase kinase-3β (GSK-3β) phosphorylates LSD1 at S683 and stabilizes LSD1 via increasing the binding of ubiquitin specific peptidase 22 with LSD1 [ 36 ]."

"40 In glioma, a lack of methionine inhibits the growth of cancer cells and enhances the binding of LSD1 to E3 ubiquitin ligase CBL (casitas B-lineage lymphoma), and increased ubiquitination of LSD1 enhances expression of CXCL8 (CXC motif chemokine ligand 8) and methylated histone H3, which in turn affects the metabolism of the glycerophospholipid.41 USP7 (ubiquitin-specific protease 7) is able to interact with LSD1, exercising deubiquitination functions and enhancing the inhibitory effect of LSD1 on p53 (tumor protein p53).42, 43, 44 Phosphorylation of LSD1 catalyzed by GSK3β promotes the binding of LSD1 to USP22 (ubiquitin specific protease 22), and deubiquitination of LSD1 promotes tumor formation.29 45 USP38 (ubiquitin-specific protease 38) interacts with LSD1 at amino acid 454 to stabilize protein level."

"Using a series of KDM1A deletion mutants, we found that KDM1A’s AOL domain was required for KDM1A’s binding with USP22 ( xref )."