IndraLab

Statements

Carnosol inhibits CASP1. 5 / 5
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"111 In addition, the active components carnosol and cryptotanshinone reduce caspase-1 activation and IL-1β secretion in MCD-induced NASH mouse model by regulating NLRP3 inflammasome activation."
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"111 In addition, the active components carnosol and cryptotanshinone reduce caspase-1 activation and IL-1β secretion in MCD-induced NASH mouse model by regulating NLRP3 inflammasome activation.112,113 Therefore, the development of small molecule compounds targeting NLRP3 inflammasome may provide new treatment strategies for complex diseases.Glycyrrhiza contains a variety of active ingredients and is one of the most commonly used Chinese medicines."
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"Our results showed that carnosol inhibited caspase-1 and IL-1beta production in a dose dependent manner, as well as the release of LDH in LPS primed BMDMs."
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"We evaluated whether carnosol treatment could prevent NLRC4 inflammasome activation, and our results showed that carnosol treatment disrupted NLRC4 dependent caspase-1 activation as well as IL-1beta secretion in Salmonella infected LPS primed BMDMs, whereas TNF-alpha production remained unchanged."
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"We observed that carnosol treatment disrupted caspase-1 cleavage and IL-1beta maturation, which were triggered by these NLRP3 inflammasome stimuli."
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