IndraLab

Statements


USP15 activates PRKN. 3 / 3
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"Furthermore, USP15 KD was able to rescue the mitophagy defect of Parkin and PINK1 mutant PD patient fibroblasts."

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"We considered the possibility that USP15 might modulate Parkin function by deubiquitinating Parkin itself."

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"Knockdown of the Drosophila homologs of USP15 (CG8334, hereafter called dUSP15) and USP30 (CG3016, hereafter dUSP30) largely rescues the mitochondrial defects of parkin deficient fly muscle in vivo."