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BACE1 activates KCNQ1. 4 / 4
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"Whereas BACE1 strongly enhanced peak KCNQ1 currents ( Fig. 1 D, red triangles), the I-V -relationship of steady-state KCNQ1 currents ( Fig. 1 D, red and black boxes) as well as their voltage dependenc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Whereas apparent current inactivation was negligible in HEK293T cells expressing KCNQ1 alone ( Fig. 1 H, black squares), co-expression of BACE1 significantly enhanced the fraction of current inactivat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, a recent study has reported that BACE1, which is also present in cardiac myocytes, modulates gating of the voltage dependent K + channels KCNQ1 and KCNE1 [XREF_BIBR]."
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"Fig. 1 BACE1 increases KCNQ1 currents in transfected HEK293T cells in the presence of 2 mM intracellular ATP."
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