IndraLab

Statements

KCNH2 activates PI3K. 6 / 6
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"HERG1 recruits and activates PI3K and Akt."
24270902
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"Wang et al. showed that human ether a-go-go-related gene 1 (HERG1) promoted ESCC cell proliferation and metastasis through activating the PI3K/Akt signaling pathway (24)."
35117695
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"HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K and AKT pathway."
31331361
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"ESEE inhibits hERG-mediated PI3K/AKT in HT29 cells."
39307030
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"These data indicate that Cla exerts its effect on CRC cell autophagy, by modulating hERG1.We previously showed that hERG1 channels stimulate the PI3K/Akt pathway by forming a macromolecular complex with the p85 subunit of PI3K, in human CRC cells ."
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"Overall, the results indicate that ESEE can target the hERG-mediated PI3K/AKT signaling pathway to induce HT29 cell apoptosis."
39307030