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MTOR phosphorylates AKT1 on S473. 16 / 24
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"Akt-1 is also phosphorylated at S473 by the mammalian target of Rapamycin (mTOR) complex referred to as (Rapamycin-insensitive companion of mTOR and mLST8 complex) mTORC2 [XREF_BIBR - XREF_BIBR]."
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"Two phosphorylation events are necessary for maximal activation of Akt, namely phosphorylation at Thr308 and Ser473 in Akt1 (Thr309/Ser474 in Akt2 and Thr305/Ser472 in Akt3) by phosphoinositide-dependent protein kinase 1 (PDK1) and the mechanistic target of rapamycin (mTOR) complex 2 (mTORC2), respectively [ xref , xref ]."
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"Akt1 is phosphorylated by PDK1 at T308, and additionally at S473 by the Pl3K related kinases, mammalian target of rapamycin complex 2 (mTORC2) or DNA-PK to achieve its full kinase activity, depending on the stimulus and the cellular context."
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"Upon activation, PIP3 binds to the PH domain, causing conformational changes and exposing Thr309 of AKT1 for phosphorylation of the kinase domain, followed by a secondary phosphorylation of AKT1 at the C-terminal Ser473, which is mediated by the mTOR complex 2 (mTORC2)."
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"AKT1 S473 is phosphorylated by the mammalian target of rapamycin (mTOR) complex 2, (mTORC2) [ xref ], a seven-subunit protein complex, including the core components mTOR and RPTOR independent companion of mTOR complex 2 (RICTOR)."
35269443
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"Mechanistic target of rapamycin complex 2 (mTORC2) is responsible for phosphorylating Akt1 at Ser473 in the C-terminal hydrophobic motif of Akt1 (Figure 1)."
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"AKT1 is phosphorylated at S473 by the mechanistic target of rapamycin complex 2 (mTORC2)."
33614606
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"Activated by receptor tyrosine kinases (RTK), mammalian target of rapamycin complex 2 (mTORC2) phosphorylates AKT1 in the HM domain at Ser473 [15] (Figure 1)."
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"This phosphorylation is essential for AKT1 activation and precedes subsequent AKT1 phosphorylation at S473 by mechanistic target of rapamycin (mTOR) complex 2 (mTORC2), to fully activate AKT [ xref , xref , xref ]."
36671478
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"Activated by receptor tyrosine kinases (RTK), mammalian target of rapamycin complex 2 (mTORC2) phosphorylates AKT1 in the HM domain at Ser473 [ xref ] ( xref )."
36497091
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"The membrane-associated AKT1 is phosphorylated at a second site by mammalian target of rapamycin complex 2 (mTORC2) on Ser473."
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"Insulin binds to the insulin receptor (INS-R) to initiate the insulin pathway signaling cascade via insulin receptor substrate (IRS) and phosphatidylinositol-3-kinase and serine/threonine protein kinase B (PKB/AKT), which is phosphorylated at serine 473 by the mechanistic target of rapamycin complex (mTORC) 2 (mTORC2), and activates an array of downstream targets including mTORC1 to initiate protein synthesis (5–11)."
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"MTOR phosphorylates AKT1 at S473, and ASZ001 mouse BCC cells treated with itraconazole, a SMO inhibitor, reduces p-S473 AKT1 expression."
33617094
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"It was previously demonstrated by our group (Pereira et al., 2012) that rapamycin inhibits formation of mTOR complex 1 (mTORC1) and 2 and insulin stimulated phosphorylation of p70S6K and protein kinas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Of note, the S473D mutant of Akt1 and Akt1 phosphorylated in Ser 473 by the rictor-mTOR complex are better targets of PDK1 than nonphosphorylated Akt1 xref ."
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"Furthermore, purified PDK-1 and immuno-precipitated mTOR readily phosphorylated purified Akt1 at T308 and S473 in vitro , respectively, regardless of whether or not TCN-P was present in the reaction mixture ( xref )."
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