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CACNA1H activates calcium(2+). 19 / 19
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"Acute naringenin treatment hyperpolarized Vgat neurons via inhibition of Cav3.2-mediated calcium currents, however, these data do not entirely exclude the possibility of a calcium influx-independent mechanism mediated by the Cav3.2 ion channel in Vgat neurons.Two different mouse models were used in this study to investigate the metabolic function of Cav3.2."
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"During neuroendocrine differentiation, Cav3.2 channels are up-regulated with increasing basal calcium entry."
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"CACNA1H mediates tumour-specific AM RF EMF Ca influx, a process that is both tumour- and tissue-specific, which indicates that cytosolic Ca oscillations is interpreted by intracellular downstream effectors, which activate different cellular processes [45]."
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"Cav3.2 T-type calcium channels, an important member of the voltage-gated calcium channel family, are sensitive to changes in cell membrane potential and allow calcium ions to participate in a variety of life activities."
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"Central among the network were calcium transport-related proteins, such as the Voltage-dependent T-type calcium channel subunits alpha-1G (CACNA1G) and alpha-1H (CACNA1H) (Fig. 2A), which mediate the entry of calcium ions into cells and is involved in cell motility, cell division, and gene expression [9, 10]."
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"This means that for these membrane potentials which are controlled by BKCa, Cav3.2 channels are open and support some entry of Ca 2 + (we named constitutive Ca 2 + entry)."
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"The knockout of UPS5 by shRNA can increase Cav3.2 ubiquitination, decrease Cav3.2 protein level, and decrease calcium current."
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"Finally, Cav3.2 and TRPV3 double KO have shown decreased fertility, altered oocyte ER Ca dynamics (fill and re-fill), and severely impaired Ca oscillations in response to fertilization (Mehregan et al., 2021)."
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"It is, however, possible that the presence of Cav3.2 channels in wt myocytes enables local Ca signaling (undetectable in our system) through interaction with RYRs in close proximity, resulting in enhanced total Ca release from the SR."
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"Moreover, in murine vascular smooth muscle cells, Cav3.2 channels are expressed in the caveolae and positioned close to RYRs to allow extracellular Ca influx to trigger Ca sparks [27,28]."
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"These elements mediate mesenteric artery dilatation through hydrogen sulfide release, promote CACNA1H-mediated calcium influx through CSE, and control mesenteric artery dilatation through hydrogen sulfide release."
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"While FH-IV denotes patients who have heterozygous gain of function germline mutations in the CACNA1H gene causing increased calcium influx and therefore aldosterone production (265)."
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"These results suggest that the identified variant in the pore region of Cav3.2 allows greater Ca influx into NPCs derived from patient F2688-1, which is consistent with the enlarged pore size predicted by the 3D-model structure of the mutant channel.Next, we sought to verify whether the mTORC1 signaling overactivation previously observed in F2688-1 NPCs [14] is due to greater influx of Ca into cells via the mutant Cav3.2 channel."
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"Notably, BCF inhibition was found to be mediated by the activation of CACNA1H, which increased intracellular influx of calcium, leading to p38 MAPK activation."
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"Notably, given that GCs lack Cav3.2 channel–mediated calcium influx throughout their maturation, we cannot rule out that other maturational-dependent mechanisms may also be occurring."
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"CACNA1H activation produces T-type Ca 2+ channels, and functional variations in CACNA1H are increased susceptibility to GGE [XREF_BIBR, XREF_BIBR]."
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"Thus, the observations depicted in Fig. 4 suggest that there is a direct but non-linear relationship between inhibition of Ca 2+ entry mediated by the Cav3.2 Ca 2+ channel and proliferation of HEK293 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, when measured by Ca 2+ -selective fluorescent dyes, Ca 2+ entry was similarly sensitive to TH-1177 and TH-1211 as was the Ca 2+ current mediated by Cav3.2."
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"This shows the pharmacological correspondence between capacitative Ca 2+ entry when measured by fluorescence and Ca 2+ entry mediated by Cav3.2 when measured by electrophysiological methods.The data p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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