IndraLab

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IGF2 binds KCNQ1. 5 / 5
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"Using a tiled probe RC-Hi-C approach, combined with a frequent 4 base-cutter restriction enzyme ( MboI ), we generated capture regions (totalling 25Mb) at 5 imprinted chromosomal loci, the largest regions included SNRPN , DLK1 - DIO3 , and IGF2-KCNQ1 (capture region IDs: CR_3, CR_2 and CR_4, respectively, Additional file xref : Table S1)."
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"These included the IGF2-KCNQ1 (BWS/SRS locus, chromosome 11p15.5), SNRPN (Prader-Willi Angelman (PWS-AS) locus, chromosome 15q11-q13), and DLK1 - DIO3 (chromosome 14q32.2) loci (Fig. xref )."
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"The IGF2-KCNQ1 locus, implicated in BWS and SRS, divides into two imprinted gene clusters, each regulated by a separate imprinting control region (ICR)."
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"Our results suggest that the aberrant methylation of IGF2 and KCNQ1 genes may be associated with sperm DNA damage."
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"These functional associations of IGF2 and KCNQ1 rely on publications reporting how a differentially methylated region in KCNQ1 controls imprinted expression of other genes in the neighborhood xref and about epigenetic abnormalities in the IGF2/H19 region of Beckwith-Wiedemann syndrome patients xref ."
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