IndraLab

Statements

(S)-naringenin inhibits KCNH2. 7 / 7
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"The IC50 value for HERG block by naringenin, the most potent inhibitor, was 102.3 micromol/L in Xenopus oocytes and 36.5 micromol/L in HEK cells."
15710766
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"HERG blockade by grapefruit flavonoid naringenin is most likely to be the mechanism underlying this effect."
16007460
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"Naringenin blocked HERG current dose dependently with an IC (50) of 173.3 +/- 3.1 microM."
18057881
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"Therefore, the electrophysiological properties of HERG blockade by naringenin were analysed in detail."
16007460
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"Naringenin blocked HERG potassium channels with an IC50 value of 102.6 microM in Xenopus oocytes."
16007460
ctd
No evidence text available
18057881
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"Naringenin 100 microM alone inhibited HERG current by 31 +/- 6%, and this inhibitory effect was increased with coadministration of 1 or 10 microM antiarrhythmic drugs."
18057881