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Ursolic acid inhibits NFKB1. 3 / 3
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"Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth restricting genes BAX, P21 and P53."
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"The anti-inflammatory, anticarcinogenic, and proapoptotic activities of ursolic acid could be correlated to its potential to inhibit the immunoregulatory transcription factor NFkB in carcinogens and inflammatory responses (Checker etal.,2012; Shishodia etal.,2003)."
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"Recently, several in vitro studies have indicated that ursolic acid inhibits NFkB activation through suppression of IkBalpha kinase and p65 phosphorylation (Shishodia et al., 2003; Zeng et al., 2011) [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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