IndraLab

Statements

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"Inhibition of USP30 After Hb Stimulation of Neurons Can Mediate Mitochondrial Protection and Attenuate Apoptosis."
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"Knockdown of USP30 could induce the mitochondrial apoptosis pathway [XREF_BIBR]."
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"Annexin V/PI staining revealed that USP30 inhibition significantly reduced apoptosis in neurons after SAH (SAH vs. SAH + MF094, 24.47 ± 0.65% vs. 10.28 ± 0.41%) (Fig. 3e)."
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"Specifically, our study demonstrates that (1) USP30 protein expression in neurons is elevated under TBI conditions in both patients and mice; (2) Neuron-specific knockout of USP30 prevents neuronal ap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In our study, USP30 inhibition reduced apoptosis for unknown reasons."
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"Liang et al. reported that USP30 inhibition reduced apoptosis by regulating the BAX/BAK pathway [31, 32]; we will follow up on the specific mechanism.The ubiquitin–proteasome system plays an important role in mitophagy [33]."
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"These results strongly suggest that USP30 inhibition reduces lesion volume, mitigates brain edema and fosters the recovery of neurological function after TBI.To determine the effects of USP30 ablation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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