IndraLab

Statements

Poly(I:C) inhibits IRF3. 3 / 4
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"Therefore, we then determined whether saturated-strength poly(I:C) and LPS challenge triggered the degradation of endogenous IRF3."
24726876
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"The NS1-K108R substitution impaired the suppression of IFN promoter activation by poly(I:C), RIG-1 CARD, TBK-1, and IRF3, which suggested that the NS1-K108R substitution affected the IFN antagonism of NS1 either through targeting downstream of IRF3 or a general mechanism that NS1 uses to inhibit IFN, such as interaction with CPSF30, resulting in inhibition of the processing of mRNA, including IFN mRNA [6]."
32093780
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"Therefore, we first determined whether exogenous SIRPα expression would inhibit IRF3 activation induced by RIG-I/MDA5-mediated detection of intercellular poly(I:C)."
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