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Poly(I:C) inhibits IRF3. 1 / 2

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"The NS1-K108R substitution impaired the suppression of IFN promoter activation by poly(I:C), RIG-1 CARD, TBK-1, and IRF3, which suggested that the NS1-K108R substitution affected the IFN antagonism of NS1 either through targeting downstream of IRF3 or a general mechanism that NS1 uses to inhibit IFN, such as interaction with CPSF30, resulting in inhibition of the processing of mRNA, including IFN mRNA [6]."

32093780

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IndraLab

Statements

Poly(I:C) inhibits IRF3. 1 / 2

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