IndraLab

Statements

USP25 inhibits IL17A. 7 / 7
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"Real-time RT-PCR analysis showed that overexpression of USP25 inhibited IL-17- but not TNF-induced expression of Cxcl1 and Il6 mRNA in HeLa cells and in 293T-IL-17RA/C cells ( xref and xref )."
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"In this study, we found that overexpression of USP25 negatively regulated IL-17- but not TNF triggered signaling."
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"However, the deubiquitinase USP25 has been shown to supress IL-17A signalling and upregulation of Usp25 therefore suggests the converse to be true ( Kanehisa and Goto, 2000 ; Monin and Gaffen, 2018 )."
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"Ubiquitin Specific Peptidase 25 (USP25) inhibits IL-17 signaling by removing Lys63-linked ubiquitination in TRAF5 and TRAF6 ( Zhong et al., 2012 )."
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"Targeting USP25 may modulate responses to IL-17, and could be beneficial in certain types of infections and cancers."
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"These data together suggest that USP25 restricts IL-17 and IL-17F signaling in various types of cells."
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"These results indicate that USP25 restricts IL17 mediated pulmonary inflammation in vivo."
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