IndraLab

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UCHL3 increases the amount of EEF1A1. 4 / 4
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"IHC analysis of the tumor in nude mouse tumors showed that UCHL3 overexpression increased EEF1A1 protein level, while UCHL3 inhibition downregulated EEF1A1 protein level (Fig. 2G-J)."

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"The experimental results showed that UCHL3 knockdown reduced the protein level of EEF1A1, and the migration ability and sphere formation ability were decreased, which was alleviated in mutated EEF1A1 group (Fig. 4G-H)."

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"The results showed that UCHL3 depletion decreased EEF1A1 protein expression, whereas UCHL3 overexpression upregulated EEF1A1 expression (Fig. 2D)."

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"UCHL3 upregulates the expression of EEF1A1 via deubiquitination, facilitating the migration of HCC cells through lysine-based interactions."