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USP8 deubiquitinates LRIG1. 4 / 5
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"Although the LRIG1 is proved to be ubiquitinated by SAIT301, the LRIG1 was deubiquitinated and stabilized by the overexpression of USP8 upon SAIT301 treatment which leading to promote lung cancer prog[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33600786
reach
"Also, when over-expressed, USP8 decreases LRIG1 ubiquitination by SAIT301 treatment (XREF_FIG)."
24828152
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"In contrast, the knockdown of USP8 increased LRIG1 ubiquitination and thus increased the LRIG1 and MET degradation by the lysosome."
33600786
reach
"To determine whether endogenous USP8 deubiquitinates LRIG1, we used shUSP8 to decrease the level of endogenous USP8 in EBC1 cells."
24828152