IndraLab

Statements

USP35 decreases the amount of CDH1. 3 / 3
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"Silencing USP35 significantly reduced N-cadherin levels and increased E-cadherin expression (p < 0.01), indicating its role in regulating EMT in KIRC cells (F ig."
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"Furthermore, we investigated the regulation of USP35 on EMT markers and found that USP35 overexpression decreased the protein levels of the epithelial marker E-cadherin and increased those of the mesenchymal markers N-cadherin and Vimentin in GC cells (Fig. 1F)."
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"The decrease in N-cadherin and increase in E-cadherin levels following USP35 knockdown indicate that USP35 actively promotes EMT, facilitating tumor invasion and metastasis."
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