IndraLab

Statements



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"Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here."

reach
"Next, we tested several small molecule inhibitors targeting NFkB signaling at different stages and identified that BMS345541 (Inhibitor of IKKbeta at IC50 0.4 muM and IKKalpha at IC50 4muM) inhibits GD2 and GD3S expression in TNBC cells [XREF_BIBR]."

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