IndraLab

Statements

Cholesterol inhibits NLRP3. 7 / 7
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"Next, we considered whether APOE might efflux cholesterol from macrophages, thereby causing a reduction in cellular cholesterol levels that activates the NLRP3 inflammasome ."
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"As shown in Figure 8B, acute depletion of cellular cholesterol using methyl-β-cyclodextrin (MβCD) induced IL-1β secretion from THP-1 macrophages, whereas its inactive analog, αCD, did not, which is consistent with activation of the NLRP3 inflammasome by cholesterol depletion."
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"Conversely, induction of cholesterol efflux from myeloid cells inhibits NLRP3 inflammasome activation 73."
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"Taken together, these results indicate that lysosomal cholesterol accumulation can decrease LMP, NLRP3 inflammasome activation, and IL-1beta release."
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"In agreement, acute depletion of the ER cholesterol pool by statin treatment abrogated the assembly and activation of the NLRP3 inflammasome."
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"We speculate that as well as triggering AIM2 and NLRP3, loss of cholesterol metabolic homeostasis activates still to be defined HAMP sensors."
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"In addition, inhibition of cholesterol efflux from neutrophils can also increase the activation of NLRP3 inflammatory bodies, promote neutrophil infiltration and release NETs, thus accelerating the formation of atherosclerotic lesions."
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