IndraLab

Statements



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"Incubation of ECs with EVs significantly inhibited the lipopolysaccharide induced (1000 ng/mL) elevation of p65 and ABCB1."

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"Pre-treating ECs with p65-antisense abolished the TNF- α -induced p65, but not p50, mRNA expression; in contrast, p65-sense did not have an inhibitory effect on the TNF- α -induced p65 expression."

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"Our in vivo data indicated that improving the activity of Wnt/β-catenin signaling in brain ECs, either directly by genetic and pharmacological approaches or indirectly by inhibiting NF-κB p65 pathway, could ameliorate BBB disruption and neuroinflammation in endotoxemia."

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"Overexpressing optimal concentrations of pre-miR-146a, -451, -98 (20 nmol/L each), and -708 (1 nmol/L) in ECs also reduced sSMC-activations of EC IkappaBalpha (XREF_FIG) and p65 (XREF_FIG)."