IndraLab

Statements

reach
"To illustrate the importance of the conformational plasticity of F656 in drug induced hERG1 blockade, we performed experimental studies of dofetilide and ivabradine binding to WT-hERG1 and a number of single and double mutations testing role of the residues comprising hydrophobic cassette in WT-hERG1 channel."
32694995
reach
"42 The modest effect of the hERG S624A mutation (XREF_FIG) and lack of close proximity of the drug to S624 in docking simulations (XREF_FIG) are consistent with an indirect role for this residue in ivabradine binding to hERG."
25911606