IndraLab

Statements

reach
"42 The modest effect of the hERG S624A mutation (XREF_FIG) and lack of close proximity of the drug to S624 in docking simulations (XREF_FIG) are consistent with an indirect role for this residue in ivabradine binding to hERG."
25911606
reach
"To illustrate the importance of the conformational plasticity of F656 in drug induced hERG1 blockade, we performed experimental studies of dofetilide and ivabradine binding to WT-hERG1 and a number of single and double mutations testing role of the residues comprising hydrophobic cassette in WT-hERG1 channel."
32694995