IndraLab

Statements

USP18 leads to the dephosphorylation of JAK1. 4 / 4
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"USP18 reduced IFN binding and receptor dimerization as well as JAK1 phosphorylation only when STAT2 was present."
28165510
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"Similarly, ubiquitin-specific peptidase 18 (USP18) interacts with IFNAR2/STAT2 and reduces JAK1 phosphorylation and activity ."
38802340
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"Following exposure to IFN-I, metallophilic macrophages induce expression of the Usp18 protein which prevents Jak1 phosphorylation and inhibits IFN-I signaling in these cells."
27769506
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"XREF_BIBR, XREF_BIBR In turn, USP18 specifically binds to the IFNAR2 subunit and thereby prevents the phosphorylation of JAK1 by blocking the interaction of JAK1 and the IFNAR2 subunit and downstream signaling."
27809302