IndraLab

Statements

OTUB1 activates NFKB2. 3 / 3
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"Preventing abnormal NF-kappaB activation and autoimmunity by Otub1 mediated p100 stabilization."
31086255
reach
"Additionally, there is evidence that OTUB-1 deficiency leads to a gradual degradation of the NF-kappaB precursor protein p100 to p52, which culminates in NF-kappaB activity induction [XREF_BIBR]."
33321885
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"Otub1 deficiency not only promotes signal induced p100 processing and noncanonical NF-kappaB activation but also causes steady-state p100 degradation, leading to aberrant NF-kappaB activation in the canonical pathway."
31086255