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USP2 activates Glucose Intolerance. 2 / 2

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"Given that USP2-4 positively regulates the expression of several glucocorticoid-regulated genes in the liver , USP2 appears to exacerbate glucose intolerance by stimulating glucocorticoid signaling [ 11 ] ."

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"Several USPs, including USP2, USP10, USP14, USP15, USP18, and USP22, have been associated with obesity and related metabolic disorders.In diet-induced obese mice, it is reported that USP2 can increase the production of hepatic glucose and promote glucose intolerance (143)."

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USP2 activates Glucose Intolerance. 2 / 2

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