IndraLab

Statements


BCR-ABL increases the amount of USP47. 3 / 3
| 3

reach
"Based on the fact that TKI reduces the expression of USP47 in CML cells and overexpression of BCR-ABL upregulates the expression of USP47 in 32D cells, we demonstrate that BCR-ABL upregulates the expression of USP47."

reach
"In contrast, BCR-ABL knockdown or IM treatment attenuates the expression of USP47 at the mRNA and protein levels."

reach
"In-depth mechanism studies have shown that BCR-ABL up-regulates the expression of USP47 through RAS/extracellular signal-regulated kinase and STAT5 signaling pathways."