IndraLab
Statements
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"Whereas otubain-1 negatively regulates GRAIL in CD4 + T cells, otubain-1 ARF-1 stabilizes GRAIL expression."
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"Otub1 forms a trimolecular complex with USP8 and GRAIL, and upregulated Otub1 promotes GRAIL 's proteosomal degradation."
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"Furthermore, addition of IL-2 was able to activate the mTOR pathway, inducing Otubain-1 expression, which mediated GRAIL degradation and improved T cell proliferation."
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"Thus, our current working model is that Otub 1 promotes GRAIL degradation by de-ubiquitination of ubiquitinated USP8, thereby diminishing USP8 activity (XREF_FIG)."
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"Interestingly, Otub1 expression completely abolished USP8 mediated stabilization of GRAIL when all 3 proteins were co-expressed."