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TNF decreases the amount of KCNH2. 1 / 1

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"We conclude that the TNF-alpha and TNFR1 system impairs HERG/I (Kr) function mainly by stimulating reactive oxygen species, particularly superoxide anion, but not by altering HERG expression; the effect may contribute to APD prolongation by TNF-alpha and may be a novel mechanism for electrophysiological abnormalities and sudden death in CHF."

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TNF decreases the amount of KCNH2. 1 / 1

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