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USP18 ubiquitinates MAVS. 2 / 2
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"Previous studies have shown that ubiquitin specific peptidase 18 (Usp18) is involved in the negative regulation of IFN-induced inflammation and is enriched in the mitochondria of virus-infected cells to promote the polyubiquitination and aggregation of mitochondrial antiviral signaling protein (MAVS) [33]."
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"We observed that knockdown of TRIM31 in HEK293T cells led to the abrogation of the enhanced K63-linked ubiquitination of MAVS by USP18 (Fig.  xref )."
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