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Statements

USP7 activates cell. 3 / 3
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"We also observed that loss of USP7 led to reduced cell proliferation and increased population of G2 phase cells ( Supplementary Fig. S2f ) , consistent with an increased p21 expression ."
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"For example , USP7 stabilizes the p53 protein to act as a tumor suppressor ( Li et al ., 2002 ) but promotes the proliferation of HCC cells via deubiquitination of YAP ( Sun et al ., 2019 ) ."
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"USP7 inhibitors effectively impair proliferation in AML cells in vitro , also independent of the USP7-MDM2-TP53 axis , and MLL-AF9-induced leukemia is delayed in vivo in human leukemia xenografts ."
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