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Dopamine inhibits NLRP3. 56 / 56
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"These results suggest that DA signals through DRD1 to inhibit inflammasome activation and signals through DRD2 to suppress the transcription proinflammatory cytokines.Next, we asked how DA and DRD1 si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine which receptor was involved in DA induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively."
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"Previous study reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."
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"In addition, dopamine negatively regulates NLRP3 inflammasome via a cAMP dependent manner."
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"show that DA inhibits the activation of the NLRP3 inflammasome through D1 receptor (DRD1) signaling."
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"Dopamine [XREF_BIBR], MCC950 [XREF_BIBR, XREF_BIBR], and CY-9 [XREF_BIBR] were reported to inhibit the NLRP3 inflammasome based on caspase-1 cleavage and mature IL-1beta release, whereas their inhibition of pyroptosis was not detected."
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"Further studies showed that knockdown of Chip or Ubr5 by using siRNA did not affect DA induced NLRP3 degradation in BMDMs."
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"Taken together, our results indicate that DA can negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggest that DRD1 might be a potential target for treatment of inflammatory di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, the neurotransmitter dopamine has also been found to inhibit the NLRP3 inflammasome via dopamine D1 receptor mediated E3-ligase activation that results in the proteasome dependent degradation of NLRP3 [XREF_BIBR]."
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"It also showed that DRD1 plays a primary role, while DRD2, DRD3, and DRD4 have no roles in dopamine mediated NLRP3 inflammasome inhibition [XREF_BIBR]."
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"In addition, dopamine significantly inhibited ventilation induced NLRP3 activation."
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"These results indicate that the increase of cAMP in cells can promote NLRP3 ubiquitination and degradation.Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we report that the neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."
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"DA, via the type-1 DA receptor-1 (DRD1) and cyclic AMP signaling, inhibits the NLRP3 inflammasome [XREF_BIBR]."
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"The results showed that inhibition of PKA with H89 did not affect DA induced NLRP3 inflammasome inhibition or DA promoted NLRP3 degradation."
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"At the same time, DA, and the D2DR agonist downregulate HMGB1/TLR4, NLRP3/IL-1β, and IL-6 while increasing IL-4 mRNA levels, suggesting the inductionTranscriptional analysis of innate immunity and pro-inflammatory pathways modulated by DA and the D2DR agonist."
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"Interestingly, dopamine was found to negatively regulate NLRP3 activation in both primary microglia and astrocytes via a dopamine D1 receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway 85."
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"NLRP3 dependent caspase-1 activation and IL-1beta maturation by nigericin were indeed inhibited by DA in a dose dependent manner."
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"Biochemical techniques including quantification of IL-1β secretion and confocal microscopy were employed to gain insight into dopamine signaling-mediated inhibition of the NLRP3 inflammasome mechanism in primary human microglia and the SYN120 transgenic mouse model."
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"Importantly, DA induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor, suggesting that DA induced NLRP3 inflammasome inhibition is cAMP dependent."
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"However, knockdown of March7 could rescue DA induced NLRP3 degradation in BMDMs."
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"Dopamine inhibits canonical, non-canonical, and α-syn-mediated activation of the NLRP3 inflammasome in primary human microglia, as does high extracellular K + ."
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"These results suggest that autophagy mediates DA induced NLRP3 degradation.We further investigated how DRD1 signaling promotes NLRP3 ubiquitination."
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"These results suggest that DA and DRD1 signaling can promote NLRP3 degradation to inhibit inflammasome activation in microglias and astrocytes."
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"These studies suggest that dopamine producing neurons and the NLRP3 inflammasome regulate each other in a bidirectional fashion, where the inflammasome can damage these neurons, while dopamine from these neurons can inhibit NLRP3 function."
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"Interestingly, we found that DA treatment induced NLRP3 degradation in a dose- and time dependent manner."
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"Further support to the possible role of the NLRP3 inflammasome in PD is based on the knowledge that dopamine neurons negatively regulate NLRP3 by the dopamine D1 receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway."
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"Here, we demonstrate that DA can induce the degradation of NLRP3 protein to inhibit NLRP3 inflammasome and support the recent findings that NLRP3 ubiquitination might play an important role in the reg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A recent study reported that dopamine might inhibit NLRP3 inflammasome via the activation of D1DR [43]."
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"It is worth noting that dopamine has been reported to inhibit NLRP3 inflammasome activation via the dopamine D1 receptor (DRD1), as DRD1 signaling induces the binding of ubiquitin to NLRP3, promoting its degradation."
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"According to previous report, dopamine inhibits NLRP3 activity via dopamine receptor D1, but not D2, in bone marrow-derived macrophages (110)."
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"In a recent study by Yan et al. [XREF_BIBR], the authors found that dopamine inhibits the NLRP3 inflammasome through the dopamine D1 receptor."
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"Biochemical techniques including quantification of IL-1β secretion and confocal microscopy were employed to gain insight into dopamine signaling-mediated inhibition of the NLRP3 inflammasome mechanism in primary human microglia and the SYN120 transgenic mouse model."
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"Importantly, DA-induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor ( Figures 4 D and 4E), suggesting that DA-induced NLRP3 inflammasome inhibition is cAMP-dependent."
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"These results suggest that DA inhibits NLRP3 inflammasome activation primary through DRD1."
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"Our results showed that autophagy inhibitor 3-Methyladenine (3-MA) could suppress DA induced NLRP3 degradation, while proteasome inhibitor MG132 could not, suggesting that ubiquitinated NLRP3 is degra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dopamine negatively regulates the NLRP3 inflammasome via cyclic adenosine monophosphate (cAMP), which binds to NLRP3 and promotes its K48 linked polyubiquitination and degradation through MARCH7 activity."
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"The reported physiological concentration of DA might be much lower than the actual concentration.Collectively, our results demonstrate that DA and DRD1 signaling can suppress NLRP3 inflammasome activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dopamine signals inhibit NLRP3 inflammasome activation through DRD1 and suppress the transcription proinflammatory cytokines through DRD2."
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"Here, our results show that DRD1 plays a primary role and DRD5 plays a minor role, while DRD2, DRD3, and DRD4 have no roles in DA-induced NLRP3 inflammasome inhibition."
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"To determine which receptor was involved in DA-induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively ( Figures S2 A and S2B)."
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"Taken together, our findings indicated that dopamine may negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggested that DRD1 might be a potential target for treatment of ICH induced inflammation."
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"Dopamine inhibits canonical, non-canonical, and α-syn-mediated activation of the NLRP3 inflammasome in primary human microglia, as does high extracellular K + ."
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"At the same time, DA, and the D2DR agonist downregulate HMGB1/TLR4, NLRP3/IL-1β, and IL-6 while increasing IL-4 mRNA levels, suggesting the induction of an antiinflammatory profile."
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"They also reported that dopamine suppresses NLRP3 inflammasome activation to control systemic inflammation [XREF_BIBR]."
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"Dopamine and bile acid suppress the NLRP3 inflammasome via DR1 signaling or TGR5 signaling and consequently enhance the production of cAMP."
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"Dopamine does not inhibit NLRP3 inflammasome activation in MARCH7 deficient macrophages."
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"Although DRD2 was not involved in DA-induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP-induced loss of the dopaminergic neurons [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further study showed that DA induced NLRP3 degradation was inhibited in Drd1 -/- macrophages, suggesting that DA promotes NLRP3 degradation via DRD1 signaling."
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"The results showed that inhibition of PKA with H89 did not affect DA-induced NLRP3 inflammasome inhibition or DA-promoted NLRP3 degradation ( Figures S4 B and S4C)."
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"Although DRD2 was not involved in DA induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP induced loss of the dopaminergic neurons [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensors for intracellular cAMP, so we tested whether they were involved in DA-induced NLRP3 inflammasome inhibiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we report that the neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."
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"Taken together, these results demonstrate that DA specifically inhibits NLRP3 inflammasome activation and subsequent IL-1beta production.Next, we investigated the mechanisms underlying the inhibitory [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Another recent study found that DA inhibits the pro inflammatory NLRP3 inflammasome response via the activation of the DA D1 receptor [XREF_BIBR]."
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"In this respect, dopamine was found to inhibit NLRP3 activation in both primary microglia and astrocytes through a dopamine D1 receptor-cyclic AMP signaling pathway XREF_BIBR."
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