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Dopamine inhibits NLRP3. 96 / 96
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"It releases a molecular drug SW033291 to achieve liver regeneration by enhancing the PGE2 level, and also releases dopamine precursor that can be transformed into dopamine by endogenous enzymes to inh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, dopamine, β-hydroxybutyric acid, nitric oxide, and unsaturated fatty acids have also been found to suppress the activity of NLRP3 inflammasome."
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"Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury induced acute lung injury."
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"The mechanism involves the phosphorylation of proteins and ubiquitination resulting in NLRP3 degradation induced by dopamine and prostaglandin-like products [97, 98]."
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"Although controversial, some have reported astrocytic NLRP3 activation (see above), with 1 study finding the dopamine D2 receptor (Drd2) inhibited NLRP3 activation in cultured astrocytes treated with LPS and ATP."
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"Dopamine inhibition of NLRP3 inflammasome is also achieved by the E3 ligase MARCH7-mediated ubiquitination of NLRP3 protein (55)."
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"A recent study reported that dopamine might inhibit NLRP3 inflammasome via the activation of D1DR [43]."
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"NLRP3 not only promoted inflammatory damage to dopamine neurons, which in turn inhibited the activation of NLRP3 ."
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"Thus, we concluded that normal dopamine neurons might upregulate endogenous lncRNA-ZFAS1 to indirectly inhibit NLRP3 activation.rTMS is a noninvasive neuromodulation technique that can effectively improve swallowing quality in PD dysphagia ."
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"Dopamine, as an endogenous factor in the central nervous system, has been found to slow down the PD process by regulating the NLRP3 inflammasome of microglia ( Pike et al., 2022 )."
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"DA has also been reported to induce NLRP3 protein degradation to inhibit NLRP3 inflammasome activation [2]."
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"Dopamine has recently been reported to inhibit NLRP3 inflammasomes."
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"Moreover, DA or A-68930 can induce NLRP3 degradation in BMDMs, and this event can be prevented in Drd1 -/- BMDMs following autophagy inhibition by 3-Methyladenine ( Yan et al., 2015 )."
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"Recent in vitro experiments confirmed that under canonical NLRP3 inflammasome activation DRD1 acts as the sole target receptor involved in DA signaling in a macrophage-like cell model and in primary h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Another study by Yan et al. has shown that dopamine can inhibit the activation of NLRP3 inflammasomes through dopamine D1 receptors in the substantia nigra via the second messenger cyclic adenosine mo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, DRD2 knockdown in BMDMs does not suppress the DA inhibitory effect on NLRP3 inflammasome, suggesting that in this model DA inhibits NLRP3 primary through DRD1 ( Yan et al., 2015 )."
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"In line with this model, the anti-inflammatory effect of DA through DRD2 is abolished in Drd2 -/- or β-arrestin2 -/- mice, leading to increased astrocyte reactivity and NLRP3 activation ( Zhu et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is worth noting that dopamine has been reported to inhibit NLRP3 inflammasome activation via the dopamine D1 receptor (DRD1), as DRD1 signaling induces the binding of ubiquitin to NLRP3, promoting its degradation."
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"Biochemical techniques including quantification of IL-1β secretion and confocal microscopy were employed to gain insight into dopamine signaling-mediated inhibition of the NLRP3 inflammasome mechanism in primary human microglia and the SYN120 transgenic mouse model."
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"Dopamine inhibits canonical, non-canonical, and α-syn-mediated activation of the NLRP3 inflammasome in primary human microglia, as does high extracellular K + ."
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"More interestingly, dopamine which is a neurotransmitter, negatively regulates the activation of NLRP3 inflammasomes."
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"Dopamine D1 receptor (DRD1) signaling mediates a negative regulation of hippocampal NLRP3 via the second messenger cyclic adenosine monophosphate (cAMP)."
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"Studies on neuroinflammation in neurodegenerative diseases, such as AD and PH, found that dopamine can downregulate the activation of the NLRP3 inflammasome, alleviating neuroinflammation [187, 188]."
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"Additionally, dopamine inhibits canonical activation as well as noncanonical activation of the NLRP3 inflammasome in primary human microglia [103]."
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"show that DA inhibits the activation of the NLRP3 inflammasome through D1 receptor (DRD1) signaling."
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"Some studies have also shown that dopamine neurons can inhibit NLRP3 activation in microglia through the DRD1-cAMP pathway."
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"Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury."
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"In macrophages, dopamine inhibits the NLRP3 inflammasome via D1R [6] , and alleviates an experimental spinal cord injury [7] , and the blockage of D2R with Haloperidol increases macrophage activity [8[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"DA, via the type-1 DA receptor-1 (DRD1) and cyclic AMP signaling, inhibits the NLRP3 inflammasome [XREF_BIBR]."
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"NLRP3 dependent caspase-1 activation and IL-1beta maturation by nigericin were indeed inhibited by DA in a dose dependent manner."
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"According to previous report, dopamine inhibits NLRP3 activity via dopamine receptor D1, but not D2, in bone marrow-derived macrophages (110)."
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"Taken together, these results demonstrate that DA specifically inhibits NLRP3 inflammasome activation and subsequent IL-1beta production.Next, we investigated the mechanisms underlying the inhibitory [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine which receptor was involved in DA induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively."
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"These results suggest that DA inhibits NLRP3 inflammasome activation primary through DRD1."
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"Electroacupuncture alleviates diesel exhaust particles-induced inflammatory response in lung through dopamine inhibition of NLRP3 signaling pathway."
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"These results suggest that DA signals through DRD1 to inhibit inflammasome activation and signals through DRD2 to suppress the transcription proinflammatory cytokines.Next, we asked how DA and DRD1 si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, we found that DA treatment induced NLRP3 degradation in a dose- and time dependent manner."
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"Further study showed that DA induced NLRP3 degradation was inhibited in Drd1 -/- macrophages, suggesting that DA promotes NLRP3 degradation via DRD1 signaling."
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"Our results showed that autophagy inhibitor 3-Methyladenine (3-MA) could suppress DA induced NLRP3 degradation, while proteasome inhibitor MG132 could not, suggesting that ubiquitinated NLRP3 is degra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results showed that inhibition of PKA with H89 did not affect DA induced NLRP3 inflammasome inhibition or DA promoted NLRP3 degradation."
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"These results suggest that autophagy mediates DA induced NLRP3 degradation.We further investigated how DRD1 signaling promotes NLRP3 ubiquitination."
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"New research in a PD mouse model shows that the DA agonist pramipexole suppresses the astrocytic NLRP3 mediated by DA receptor D3 protein-dependent autophagy [169]."
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"Importantly, DA induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor, suggesting that DA induced NLRP3 inflammasome inhibition is cAMP dependent."
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"These results indicate that the increase of cAMP in cells can promote NLRP3 ubiquitination and degradation.Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, the neurotransmitter dopamine has also been found to inhibit the NLRP3 inflammasome via dopamine D1 receptor mediated E3-ligase activation that results in the proteasome dependent degradation of NLRP3 [XREF_BIBR]."
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"However, knockdown of March7 could rescue DA induced NLRP3 degradation in BMDMs."
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"These results suggest that DA and DRD1 signaling can promote NLRP3 degradation to inhibit inflammasome activation in microglias and astrocytes."
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"Further support to the possible role of the NLRP3 inflammasome in PD is based on the knowledge that dopamine neurons negatively regulate NLRP3 by the dopamine D1 receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway."
| PMC
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"AII/AII junctional communication is reduced by dopamine or forskolin, indicating a cAMP-mediated regulation of these gap junction channels."
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"Dopamine does not inhibit NLRP3 inflammasome activation in MARCH7 deficient macrophages."
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"Dopamine [XREF_BIBR], MCC950 [XREF_BIBR, XREF_BIBR], and CY-9 [XREF_BIBR] were reported to inhibit the NLRP3 inflammasome based on caspase-1 cleavage and mature IL-1beta release, whereas their inhibition of pyroptosis was not detected."
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"Further studies showed that knockdown of Chip or Ubr5 by using siRNA did not affect DA induced NLRP3 degradation in BMDMs."
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"To determine which receptor was involved in DA-induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively ( Figures S2 A and S2B)."
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"Dopamine and bile acid suppress the NLRP3 inflammasome via DR1 signaling or TGR5 signaling and consequently enhance the production of cAMP."
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"In MPTP-induced PD mice and human microglia, dopamine inhibits the activation of microglial NLRP3 inflammasome through signaling via DRD1 and DRD2, leading to the ubiquitination and subsequent degradation of NLRP3."
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"Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of beta-arrestin2 and NLRP3."
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"Taken together, our results indicate that DA can negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggest that DRD1 might be a potential target for treatment of inflammatory di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we demonstrate that DA can induce the degradation of NLRP3 protein to inhibit NLRP3 inflammasome and support the recent findings that NLRP3 ubiquitination might play an important role in the reg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although DRD2 was not involved in DA induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP induced loss of the dopaminergic neurons [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition to DRD1, the D2 receptor (DRD2) may also be involved in the DA-induced inhibition of the NLRP3 inflammasome [81]."
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"In a recent study by Yan et al. [XREF_BIBR], the authors found that dopamine inhibits the NLRP3 inflammasome through the dopamine D1 receptor."
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"Dopamine, as an anti-inflammatory substance, can significantly reduce lung tissue damage in rats by inhibiting the NLRP3 signaling pathway, which is a potentially effective treatment strategy for VILI (Yang et al., 2017)."
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"The reported physiological concentration of DA might be much lower than the actual concentration.Collectively, our results demonstrate that DA and DRD1 signaling can suppress NLRP3 inflammasome activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, DA-induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor ( Figures 4 D and 4E), suggesting that DA-induced NLRP3 inflammasome inhibition is cAMP-dependent."
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"They also reported that dopamine suppresses NLRP3 inflammasome activation to control systemic inflammation [XREF_BIBR]."
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"Biochemical techniques including quantification of IL-1β secretion and confocal microscopy were employed to gain insight into dopamine signaling-mediated inhibition of the NLRP3 inflammasome mechanism in primary human microglia and the SYN120 transgenic mouse model."
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"Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensors for intracellular cAMP, so we tested whether they were involved in DA-induced NLRP3 inflammasome inhibiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dopamine inhibits canonical, non-canonical, and α-syn-mediated activation of the NLRP3 inflammasome in primary human microglia, as does high extracellular K + ."
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"The results showed that inhibition of PKA with H89 did not affect DA-induced NLRP3 inflammasome inhibition or DA-promoted NLRP3 degradation ( Figures S4 B and S4C)."
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"Further studies indicated that dopamine negatively regulates the NLRP3 inflammasome through the G protein pathway."
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"In this respect, dopamine was found to inhibit NLRP3 activation in both primary microglia and astrocytes through a dopamine D1 receptor-cyclic AMP signaling pathway XREF_BIBR."
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"Dopamine D2 receptor (Drd2) inhibits the activation of NLRP3 by regulating β-arrestin2 interaction with NLRP3 and interferes with the inflammasome assembly."
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"In addition, dopamine negatively regulates NLRP3 inflammasome via a cAMP dependent manner."
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"Dopamine D receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway negatively regulates NLRP3 inflammasome in both primary microglia and astrocytes."
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"Previous study reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."
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"DA, via the type-1 DA receptor-1 (DRD1) and cyclic AMP signaling inhibits the NLRP3 inflammasome (Yan et al., 2015)."
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"Taken together, our findings indicated that dopamine may negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggested that DRD1 might be a potential target for treatment of ICH induced inflammation."
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"From this result, DNP slightly reduced the expression of NLRP3 compared with the control group, which may be due to the dopamine-mediated inhibition of NLRP3."
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"Dopamine signals inhibit NLRP3 inflammasome activation through DRD1 and suppress the transcription proinflammatory cytokines through DRD2."
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"Interestingly, DA may also inhibit the canonical, non-canonical, and α-syn-mediated activation of the NLRP3 inflammasome in vitro: a mechanism involved in DOPAn loss."
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"Interestingly, dopamine was found to negatively regulate NLRP3 activation in both primary microglia and astrocytes via a dopamine D1 receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway 85."
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"These studies suggest that dopamine producing neurons and the NLRP3 inflammasome regulate each other in a bidirectional fashion, where the inflammasome can damage these neurons, while dopamine from these neurons can inhibit NLRP3 function."
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"More specifically, DA is demonstrated to inhibit production of angiotensinogen/AII in astrocytes via D2R [ 55 ]."
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"Here, our results show that DRD1 plays a primary role and DRD5 plays a minor role, while DRD2, DRD3, and DRD4 have no roles in DA-induced NLRP3 inflammasome inhibition."
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"Interestingly, Yan et al. have found that the neurotransmitter dopamine suppresses the NLRP3 inflammasome via dopamine D1 receptor-mediated E3-ligase activation that results in proteasome-dependent de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although DRD2 was not involved in DA-induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP-induced loss of the dopaminergic neurons [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Meanwhile, we found that administration of DA could significantly attenuate the mechanical ventilator-induced up-regulation of NLRP3 and Caspase-1."
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"In addition, dopamine can inhibit NLRP3 inflammasome and reduce pro-inflammatory factor release by decreasing levels of NLRP3, ASC, and caspase-1 in SCI mouse models (Jiang et al., 2023a); moreover, the dopamine D1 receptor agonist A-68930 has the same effect (Jiang et al., 2016b)."
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"Some studies have shown that dopamine released from dopaminergic neurons can inhibit NLRP3 activation in microglia through the DRD1-CAMP pathway [33,59]."
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"Another recent study found that DA inhibits the pro inflammatory NLRP3 inflammasome response via the activation of the DA D1 receptor [XREF_BIBR]."
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"Intriguingly, microglia express dopaminergic receptors (DR), through which dopamine can inhibit the inflammatory response, including the production of IL-1β and IL-18, by promoting the degradation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dopamine negatively regulates the NLRP3 inflammasome via cyclic adenosine monophosphate (cAMP), which binds to NLRP3 and promotes its K48 linked polyubiquitination and degradation through MARCH7 activity."
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"Moreover, in bone marrow-derived macrophages, dopamine could inhibit NLRP3 inflammasome through DR1 pathway causing cAMP accumulation and promoting ubiquitin [12] ."
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"It also showed that DRD1 plays a primary role, while DRD2, DRD3, and DRD4 have no roles in dopamine mediated NLRP3 inflammasome inhibition [XREF_BIBR]."
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"As reported previously, DA was able to inhibit the activation of the NLRP3 inflammasome via the dopamine D1 receptor, thereby down-regulating the systemic inflammatory response ( Yan et al., 2015 )."
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"Endogenous dopamine has been demonstrated to inhibit NLRP3 complex assembly via signaling through dopamine receptors D1 and D2 (DRD1 and DRD2) [77,78]."
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