IndraLab

Statements

USP2 binds DCAF1. 14 / 14
4 | 3 7
reach
"This interaction appears to be direct since purified Flag-VPRBP binds a purified GST-USP2 fusion protein but not GST alone (Fig. 5d)."
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"Collectively, these results indicate that USP2 binds, deubiquitinates, and thereby stabilizes VPRBP in vivo (Supplementary Fig. 1)."
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sparser
"Interestingly, we found that the USP2-VPRBP axis modulates PD-L1 expression in a p53-independent manner through two distinct mechanisms (Supplementary Fig.  xref )."
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"Here we show that VPRBP levels are tightly controlled by USP2, a deubiquitinase that binds and stabilizes VPRBP, and that loss of USP2 function can activate p53 responses, including its tumor suppressive effects."
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biogrid
No evidence text available
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biogrid
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sparser
"Interestingly, the USP2-VPRBP axis also regulates PD-L1 (programmed death-ligand 1) expression."
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sparser
"As both mechanisms serve to reduce PD-L1 levels (Supplementary Fig.  xref ), the USP2-VPRBP axis should suppress PD-L1-mediated immune evasion and thereby enhance tumor immunosurveillance."
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biogrid
No evidence text available
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biogrid
No evidence text available
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sparser
"Nevertheless, the USP2-VPRBP axis is able to target both PD-L1 and p53 simultaneously."
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sparser
"To further validate this interaction, we first examined whether USP2 interacts with VPRBP in the cells through co-transfection."
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"In this study, we identified the USP2-VPRBP axis as a pathway by which p53 function is regulated in tumor cells."
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"Moreover, co-immunoprecipitation analysis of human melanoma A375 cell extracts indicate that endogenous VPRBP and USP2 proteins interact in vivo (Fig.  xref )."
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