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AMPK phosphorylates KCNB1. 5 / 5
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"Since we have shown that AMPK activation was significantly impaired by HCV infection ( xref ), it will be of great interest to see how Kv2.1 phosphorylation by AMPK is affected during either HCV infection or NS5A expression."
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"Functionally, AMPK phosphorylates voltage-gated K+ channel (Kv2.1) and thereby confers a leftward shift in both the activation and inactivation curves of Kv2.1, which precipitates an increase in the intracellular Ca2+ concentration (Evans et al., 2009)."
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"AMPK phosphorylates purified Kv2.1 at two sites in its cytoplasmic C-terminal tail, and the effect of AMPK activation on voltage gating was lost in cells in which one of these (Ser440) was substituted with a non-phosphorylatable alanine xref ."
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"We identified two sites (S440 and S537) directly phosphorylated on Kv2.1 by AMPK and, using phosphospecific antibodies and quantitative mass spectrometry, show that phosphorylation of both sites increased in A-769662-treated cells."
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"Similar to KV1.5, AMPK phosphorylates KV2.1 in cell-free assays and in intact cells at two sites (Ser440 and Ser537) within the C-terminal cytoplasmic tail [46]."
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