IndraLab

Statements

AMPK phosphorylates KCNB1. 6 / 6
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"Other studies have shown that AMPK-dependent phosphorylation of Kv2.1 has implications on neuronal metabolic stress ( xref ) and dual phosphorylation at N-terminal Y124 and C-terminal S800 by Src and p38, respectively, is required in proapoptotic Kv2.1 membrane insertion in injured neurons ( xref )."
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rlimsp
"Since we have shown that AMPK activation was significantly impaired by HCV infection (46), it will be of great interest to see how Kv2.1 phosphorylation by AMPK is affected during either HCV infection or NS5A expression."
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"We identified two sites (S440 and S537) directly phosphorylated on Kv2.1 by AMPK and, using phosphospecific antibodies and quantitative mass spectrometry, show that phosphorylation of both sites increased in A-769662-treated cells."
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"AMPK phosphorylates purified Kv2.1 at two sites in its cytoplasmic C-terminal tail, and the effect of AMPK activation on voltage gating was lost in cells in which one of these (Ser440) was substituted with a non-phosphorylatable alanine xref ."
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sparser
"Since we have shown that AMPK activation was significantly impaired by HCV infection ( xref ), it will be of great interest to see how Kv2.1 phosphorylation by AMPK is affected during either HCV infection or NS5A expression."
23857585
reach
"Functionally, AMPK phosphorylates voltage-gated K+ channel (Kv2.1) and thereby confers a leftward shift in both the activation and inactivation curves of Kv2.1, which precipitates an increase in the intracellular Ca2+ concentration (Evans et al., 2009)."
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