IndraLab

Statements

USP8 binds BIRC6 and MCPH1. 5 / 5
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sparser
"Here we show that the UBC domain, not the BIR domain, is required for BRUCE to promote DNA repair at a step post the formation of BRUCE-USP8-BRIT1 complex."
26683461
sparser
"Specifically, the BIR is dispensible for the scaffold function of BRUCE in tethering USP8 and BRIT1 forming the nuclear BRUCE-USP8-BRIT1 complex [ xref ]."
26683461
sparser
"The formation of the BRUCE-USP8-BRIT1 complex in unstimulated cells is mediated by N-terminal half of BRUCE (N-BRUCE)."
26683461
sparser
"In the recently elucidated role of BRUCE in the regulation of DNA damage signaling and repair, neither the BIR or UBC is required for the scaffold function of BRUCE in the formation of BRUCE-USP8-BRIT1 complex [ xref ]."
26683461
sparser
"Together, these results indicate that subsequent to the formation of the BRUCE-USP8-BRIT1 complex mediated by N-BRUCE, the C-BRUCE is required for targeting BRIT1 to DSB sites."
26683461