IndraLab

Statements

USP7 inhibits PRC1. 3 / 3
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"Examination of the PRC1 regulated INK4a locus found depletion of both USP7 and USP11 resulted in expression of p16 INK4a at the transcript and protein level, and decreased binding of PRC1 members at the INK4a locus as assessed by ChIP."
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"It suggests that USP7 depletion induced disassembly of PRC1 and dissociation of RYBP from chromatin."
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"Similarly, Hu et al. concluded that HSCARG and USP7 downregulate PRC1, downregulating the H2A ubiquitination and promoting cell proliferation [125] ."
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