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USP10 deubiquitinates MSH2. 2 / 3
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"MSH2 is also phosphorylated by NPM-ALK at tyrosine 238 by oncogenic fusion protein NPM-ALK, leading to impaired MMR in anaplastic large cell lymphoma.24 Histone deacetylase 6 (HDAC6) and HDAC10 were found to separately deacetylate MSH2 at distinct sites of its C-terminus and N-terminus, which increases MSH2 ubiquitination and degradation and ultimately reduces DNA MMR activities.25 26 Conversely, ubiquitin-specific peptidase 10 (USP10) deubiquitinates MSH2 and compromises DNA damage response and MMR activity.27Protein arginine methyltransferases (PRMTs) are a family of enzymes that catalyze protein arginine methylation."
40086819
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"USP10 deubiquitinates MSH2 in vitro and in vivo Moreover, the protein level of MSH2 is positively correlated with the USP10 protein level in a panel of lung cancer cell lines."
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